The concentration of the proteins S100A8 and S100A9 in serum increases during an inflammatory response. Patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) show elevated serum levels of S100A8 and S100A9. Additionally, the S100A8/A9 complex is considered a biomarker of SARS-CoV-2 infection and is involved in inducing cytokine storms.
A new study investigates the role of the S100A8/A9 complex in the replication of the human immunodeficiency virus (HIV). The findings of this study provide insights into the regulation of HIV viral loads in SARS-CoV2 co-infection. A preprint version of the study, which is yet to undergo peer review, is available on the bioRxiv* server.
