TxCell SA (FR0010127662 – TXCL), a biotechnology company developing innovative, personalized T-cell immunotherapies using antigen specific regulatory T-cells (Ag-Tregs) for severe chronic inflammatory and autoimmune diseases, today announces that activity and tolerance data for its second lead product Col-Treg were presented through a poster presentation at the 2015 ARVO Annual Meeting, May 3-7, 2015, in Denver, Colorado, US.
The presentation was delivered by Dr. Hélène Asnagli, Preclinical Pharmacology & Safety Director, in the session entitled ‘AMD immunobiology, autoimmunity, and immunoregulation’. The poster entitled ‘Immunotherapy of Non-Infectious Uveitis using Collagen II-specific regulatory Type 1 (Col-Treg) cells’ presented preclinical efficacy and tolerability results with Col-Treg in the treatment of autoimmune uveitis.
These results include pharmacokinetic and pharmacodynamic data showing a reduction in the severity of uveitis on clinical and histologic measures. In addition, TxCell has also generated GLP toxicology results that indicate a good safety profile for Col-Treg. Col-Treg is set to start a phase I/II placebo-controlled, dose-ranging proof of principle clinical study in autoimmune uveitis mid-2015.
