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Structural analysis of COVID-19 spike protein provides insight into its evolution

A characterising feature of SARS-CoV-2, the virus that causes COVID-19, is the protein spikes which cover the surface, which the virus uses to bind with and enter human cells.

Analysing the structure of these spikes could provide clues about the virus’ evolution. It is not yet known how SARS-CoV-2 evolved to infect humans and whether this happened directly from coronaviruses in bats or via an intermediary species.

In their study, published in Nature Structural & Molecular Biology, the researchers characterised the spike protein in high resolution using a technique called cryo-electron microscopy, which allowed them to achieve a greater level of detail than previously reported structures.

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