A team of researchers at the University of Adelaide has found a link between the way that cells produce energy for brain function and the mutated genes found in Alzheimer’s disease.
The discovery published in Disease Models and Mechanisms has prompted further examination of the link as a fundamental, early driver of Alzheimer’s disease in humans.
In the study, the researchers analysed the young adult brains of zebrafish with gene mutations associated with early-onset Alzheimer’s disease. Zebrafish were chosen for the study because they produce very large families, which makes it easier to detect subtle effects.
