A Singapore team led by clinician-scientists and researchers from the National Cancer Centre Singapore (NCCS) discovered a genetic link to better predict treatment response for relapsed/refractory patients with natural- killer T-cell lymphoma (NKTCL), a highly aggressive form of blood cancer.
The team performed whole-genome sequencing, to identify mutation in PD-L1 gene as a reliable biomarker to identify lymphoma patients with a high likelihood of positive response to anti PD-1 therapy, a type of immunotherapy, which has shown promising therapeutic results. The landmark findings were recently published in high-impact factor journal, Leukemia.
