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Natural killer cells mediate a trade-off between wound healing and bacterial defense

September 8, 2021

Natural killer cells do not just kill cancer cells or cells infected with viruses, they also mediate a trade-off between wound healing and bacterial defense in skin wounds. If the healing process is accelerated, the immune defense is weakened, researchers at the University of Zurich have now shown. This has relevance in treating skin injuries and in tackling antibiotic-resistant germs.

Natural killer cells are a specific type of immune cell. They recognize abnormal body cells such as cancer cells or virus-infected cells, and eliminate them. An international research team led by Christian Stockmann, professor at the Institute of Anatomy at the University of Zurich (UZH), has now discovered that killer cells have another – surprising – function: They manage wound healing in the skin.

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