In a new study led by Yale Cancer Center, researchers show the nucleoside transporter ENT2 may offer an unexpected path to circumventing the blood-brain barrier (BBB) and enabling targeted treatment of brain tumors with a cell-penetrating anti-DNA autoantibody. The study was published today online in the Journal of Clinical Investigation Insight.
“These findings are very encouraging as the BBB prevents most antibodies from penetrating the central nervous system and limits conventional antibody-based approaches to brain tumors,” said James E. Hansen, MD, Associate Professor of Therapeutic Radiology, Radiation Oncology Chief of the Yale Gamma Knife Center at Smilow Cancer Hospital, and corresponding author of the study.
