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Detailed structure of protein pair offers blueprint for new medicines

June 4, 2018

Walter and Eliza Hall Institute researchers have visualized for the first time how the protein SOCS1 ‘switches off’ cell signaling to dampen immune responses and block cancer growth.

The atomic-level structure of SOCS1 binding to its partner protein JAK could guide the development of drugs that alter disease-causing cell signaling pathways, and may have applications for treating some blood cancers, including leukemias.

The research, led by Dr Nick Liau, Dr Nadia Kershaw, Associate Professor Jeff Babon and Professor Nick Nicola, was published in the journal Nature Communications.

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