Viral infections may have enormous global impacts, as evidenced by the recent coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). History has many other examples, such as the Ebola epidemics of 2013- 2016, the H1N1 pandemic of 2009-2010, etc. Structural biology aims to determine how antibodies elicited during infection or vaccination target viral proteins. A new review published in Viruses reviews how molecular and structural biology have contributed to our understanding of antibody recognition of HIV-1, SARS-CoV-2, and Zika.