Drug diversion is an increasingly serious issue that tends to be substantially underestimated. In every instance, a potential threat to patient safety is present. This includes the risk of inadequate pain relief, exposure to infectious diseases through contaminated needles or drugs, and risks associated with unsafe care from impaired healthcare workers. Drug diversion can also pose risks to staff safety and regulatory compliance, as can be seen across all types of healthcare facilities and, across all clinical disciplines. Healthcare organizations face financial penalties, potentially in the millions, for lack of compliance with DEA regulations leading to diversion within their hospitals.