Researchers at Okayama University describe in Scientific Reports that cancer-associated fibroblasts — cells that play a key role in cancer progression — originate from cancer stem cells. Preventing cancer stem cells from transforming into cancer-associated fibroblast may be a promising approach towards cancer treatment.
Cancer progression is partly governed by a specialized type of cells known as cancer-associated fibroblasts (CAFs), as they have the ability to support/mediate different signaling pathways in a tumor microenvironment. However, it is still unclear that how CAFs are generated.
