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AI and single-cell genomics

August 3, 2020

Researchers from the Institute of Computational Biology at Helmholtz Zentrum München and the Department of Mathematics at TUM developed “scVelo” (single-cell velocity). The method estimates RNA velocity with an AI-based model by solving the full gene-wise transcriptional dynamics. This allows them to generalize the concept of RNA velocity to a wide variety of biological systems including dynamic populations.

“We have used scVelo to reveal cell development in the endocrine pancreas, in the hippocampus, and to study dynamic processes in lung regeneration — and this is just the beginning,” says Volker Bergen, main creator of scVelo and first author of the corresponding study in Nature Biotechnology.

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