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image: Caitlin Murdoch

Study reveals how the microbiota controls activity of immune cells

March 8, 2019

A host protein called Serum Amyloid A (Saa) is a major factor mediating the effects of the microbiota on the function of immune cells called neutrophils, according to a study published March 7 in the open-access journal PLOS Pathogens by John Rawls of Duke University School of Medicine, and colleagues. Experiments in zebrafish showed that Saa produced by the intestine in response to the microbiota serves as a signal to neutrophils to restrict aberrant activation, decreasing inflammation and bacterial killing potential while simultaneously enhancing their ability to migrate to wounds.

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