Researchers report encouraging preclinical results as they pursue elusive therapeutic strategies to repair scarred and poorly functioning heart tissues after cardiac injury – describing an experimental molecular treatment for heart failure.
In an Aug. 22 study in the Journal of the American College of Cardiology, researchers at the Cincinnati Children’s Heart Institute inhibited a protein that helps regulate the heart’s response to adrenaline. This alleviated the disease processes in mouse models of human heart failure, and in cardiac cells isolated from heart failure patients undergoing reparative surgery.
