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Scientist uncovers clues to aging in mitochondria

May 18, 2022


Many age-related diseases share a common feature: the mitochondria of cells begin to malfunction. While the cause is not known, Buck Institute scientists have discovered a new mechanism of how mitochondria start to go wrong, which opens new doors for researchers to explore how to begin to fix the problem.

“Now that we have this different hypothesis of why mitochondrial dysfunction happens during aging and age-related diseases, we open a completely different way to think about, measure, mitigate and reverse that process,” said Buck Fellow Chuankai (Kai) Zhou, PhD, who is the senior author of a study published in the March 2 issue of eLife, a leading journal on biomedical research established by the Howard Hughes Medical Institute, Max Planck Society, and Wellcome Trust.

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