The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein has been the main target for the development of vaccines and other therapeutics needed to treat COVID-19 illness. New research published in the journal Future Medicine found the SARS-CoV-2 spike glycoprotein has druggable cavities with the best target being compatible with more than 1 billion compounds.
One compound known as Compound 38 had the highest affinity to a SARS-CoV-2 cavity and prevents viral entry. Results suggest it meddles with the interaction between the SARS-CoV-2 receptor binding domain and the human ACE2 receptor.
