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Rare mutations may have big impact on schizophrenia pathology

March 9, 2021

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Schizophrenia is a neurodevelopmental disorder that disrupts brain activity producing hallucinations, delusions, and other cognitive disturbances. Researchers have long searched for genetic influences in the disease, but genetic mutations have been identified in only a small fraction — fewer than a quarter — of sequenced patients. A new study now shows that “somatic” gene mutations in brain cells could account for some of the disease neuropathology.

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