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Protecting the brain from dementia-inducing abnormal protein aggregates

July 1, 2022

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Neurodegenerative diseases like Alzheimer’s and Parkinson’s are defined by pathogenic accumulation of toxic proteins in the brain. Now, however, scientists from the National Institutes for Quantum Science and Technology have established that the p62 protein, which is involved in cellular protein degradation, can prevent the accumulation of toxic oligomeric tau species in mouse brains, proving — for the first time — the “neuroprotective” function of p62 in a living model.

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