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Polymer-coated nanoparticles to promote drug delivery to the brain

November 5, 2021

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Treating diseases such as Alzheimer’s or Parkinson’s is a challenge because drugs have to be able to cross the blood-brain barrier. As a result, the doses administered must be high and only a small fraction reaches the brain, which can lead to significant systemic side effects. To solve this issue, the postdoctoral researcher Jean-Michel Rabanel, under the supervison of Professor Charles Ramassamy, at the Institut national de la recherche scientifique (NRS), is optimizing polymer-coated nanoparticles to increase their permeability across this barrier and consequently the delivery of encapsulated drugs in the brain.

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