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Impact of type I interferon (IFN) autoantibodies in critical COVID-19

March 12, 2021

The emergence and rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has triggered the coronavirus disease 2019 (COVID-19) pandemic. To date, over 118 million cases have been confirmed, and over 2.6 million have lost their lives. The sheer scale of the outbreak is perplexing, seconded only by the scale of heterogeneity in the clinical presentation of the infection.

A new preprint, released on the bioRxiv* server, discusses the pathogenesis of this condition with reference to autoimmune phenomena involving the key antiviral type I interferon pathway.

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