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Can limiting the priming dose of a SARS-CoV-2 vaccine improve immunity?

April 6, 2021


Several vaccines have been developed, approved and rolled out to prevent coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, some concern is mounting that a sufficient number of vaccine doses may not be available to promptly promote global herd immunity. This predicament has led researchers to explore the possibility of administering partial vaccine doses to boost coverage.

But this, in turn, raises the question of how vaccine fractionation affects vaccine-elicited immunity. In a vaccine fractionation (also known as dose-sparing), a smaller amount of antigen would be used per dose to increase the number of persons who can be vaccinated with a given quantity of vaccine.

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