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Antibody treatment prevents inflammation in lungs, nervous system in macaques with SARS-CoV-2, study finds

November 1, 2021


Monoclonal antibodies protected aged, diabetic rhesus macaque monkeys from disease due to SARS-CoV-2 and reduced signs of inflammation, including in cerebrospinal fluid, according to a new study from researchers at the University of California, Davis. The work is published Oct. 18 in the journal Cell Reports.

The data show that neutralizing antibodies prevent the adverse inflammatory consequences of SARS-CoV-2 infection, the authors said. The results help explain how antibodies, whether induced by vaccines or after infection, or given as a treatment, can affect the course of disease. They also suggest that antibodies could be given as a preventative treatment to people at high risk, such as elderly residents during an outbreak in a nursing home.

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