A 50-year-old lab technique is helping researchers better understand circular DNA, a lesser-known and poorly understood cousin of the linear version commonly associated with life’s genetic blueprint.
With the aid of a process called density gradient centrifugation, a research team, which included scientists from The University of Texas at Dallas and Stanford University School of Medicine, recently published a study that for the first time characterizes all of the circular DNA in the worm C. elegans, as well as in three human cell types.
