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New molecular mechanism that regulates the sentinel cells of the immune system

April 3, 2020

CNIC’s study suggests that it may be possible to regulate the number and activity of these macrophages with drugs that modulate the nuclear receptor RXR.

A team at the Centro Nacional de Investigaciones Cardiovasculares (CNIC), working in partnership with researchers at Mount Sinai Hospital in New York, has discovered a new molecular mechanism mediated by nuclear receptors that determines the identity and expansion of macrophages–one of the cell types that act as immune sentinels in the body.

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