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Inhibition of SARS-CoV-2 helicase by single DNA lesions

October 18, 2021

The genome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encodes for several non-structural proteins (NSP) involved in viral replication and propagation, with NSP13 known to play a role in RNA unwinding and subsequent transcription of the single-stranded template.

The NSP13 helicase may be inhibited by preventing interaction with target DNA. In a paper recently uploaded to the preprint server bioRxiv*, the impact of specific DNA lesions is investigated regarding the unwinding activity of NSP13.

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