Glioblastoma is an aggressive brain cancer that progresses very rapidly and often becomes treatment resistant. The commonest chemotherapy drug used to treat glioblastoma, temozolomide, tends not to be as effective as one might hope. But could a common altitude sickness drug enhance its success?
Temozolomide (TMZ) works by modifying DNA, so that certain proteins that allow the tumors to grow and expand do not express.
But, some tumor cells are able to “resist” TMZ’s action.