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Researchers discover unexpected role for the clock gene in prostate cancer progression

January 15, 2021

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Our biological or circadian clock synchronizes all our bodily processes to the natural rhythms of light and dark. It’s no wonder then that disrupting the clock can wreak havoc on our body. In fact, studies have shown that when circadian rhythms are disturbed through sleep deprivation, jet lag, or shift work, there is an increased incidence of some cancers including prostate cancer, which is the second leading cause of cancer death for men in the U.S.

With an urgent need to develop novel therapeutic targets for prostate cancer, researchers at the Sidney Kimmel Cancer – Jefferson Health (SKCC) explored the circadian clock and found an unexpected role for the clock gene CRY-1 in cancer progression.

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