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Researchers discover a hormone that might help tackle malabsorption

September 22, 2020

Scientists at Cincinnati Children’s used human intestinal organoids grown from stem cells to discover how our bodies control the absorption of nutrients from the food we eat.

They further found that one hormone might be able to reverse a congenital disorder in babies who cannot adequately absorb nutrients and need intravenous feeding to survive.

Heather A. McCauley, PhD, a research associate at Cincinnati Children’s Hospital Medical Center, found that the hormone peptide YY, also called PYY, can reverse congenital malabsorption in mice. With a single PYY injection per day, 80% of the mice survived. Normally, only 20% to 30% survive.

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