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Researchers discover mechanism linking mutations in the ‘dark matter’ of the genome to cancer

June 13, 2022

For many years, the human genome was viewed as a book of life in which sections of great eloquence and economy of expression were interspersed with vast stretches of gibberish. The legible sections contained the code for making cell proteins; the other regions, representing about 90% of the entire genome, were dismissed as “junk DNA,” having no discernable purpose.

Research has taught scientists otherwise. Far from being useless filler, many non-coding sections have been shown to play a key role in regulating gene activity — increasing or decreasing it as needed.

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