Endometrial cancer is the most common gynecologic cancer in the U.S. Most cases are diagnosed at early stage and have good prognosis. Unfortunately, some patients with early stage and low grade endometrial cancer experience recurrence — and the reasons are not entirely clear. When recurrence happens, the cancer is often resistant to chemotherapy and has a high rate of mortality.
New research from the lab of Martina Bazzaro, Ph.D., of the Masonic Cancer Center, University of Minnesota and Department of Obstetrics, Gynecology, and Women’s Health, suggests the deubiquitinating enzyme (DUB) USP14 as a promising biomarker for identifying risk of recurrence in endometrial cancer patients.
