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Tag: Immunotherapy


Innovation, Research

Mathematical modeling to explain immunotherapy responses

July 26, 2022

Via: ScienceDaily

Immunotherapies that activate the immune system to seek and kill cancer cells have greatly improved outcomes for many patients with solid tumors. There is still, however, a subset of patients who do not see benefit from this type of therapy. […]


Innovation, Research

Immunotherapy may get a boost

June 11, 2022

Via: ScienceDaily

T cells are usually very good at eliminating diseased cells. But they seem to fail when it comes to tumor cells. In JCI Insight, MDC teams led by Armin Rehm and Uta Höpken describe what inhibits this immune function, how […]


Innovation, Research

Novel treatment makes pancreatic cancer susceptible to immunotherapy, mouse study shows

March 7, 2022

Via: ScienceDaily

Pancreatic cancer is one of the most aggressive and deadly tumor types and notorious for its resistance to virtually all types of treatment, including newer immunotherapies. A new study — in mice — from Washington University School of Medicine in […]


News

Changing the standard of care for stage III melanoma surgery

March 4, 2022

Via: ScienceDaily

For years, surgery for patients with stage III melanoma — melanoma that has spread to the lymph nodes — involved removing those lymph nodes along with the primary tumor. Known as completion lymph node dissection (CLND), the surgery was meant […]


Innovation, Research

Immunotherapy before surgery killed off liver tumors in one-third of patients, study finds

January 27, 2022

Via: Fox News

Liver tumors died off in a third of patients enrolled in a study who received immunotherapy treatment before surgery, according to Mount Sinai researchers in New York City. The study was recently published in The Lancet Gastroenterology & Hepatology. Liver […]


Biomarker, Innovation

Cancer cells disarm cellular attackers by extending out nanoscale tentacles

November 18, 2021

Via: The Medical News

To grow and spread, cancer cells must evade the immune system. Investigators from Brigham and Women’s Hospital and MIT used the power of nanotechnology to discover a new way that cancer can disarm its would-be cellular attackers by extending out […]


Biomarker, Innovation

New cancer findings can give wider access to immunotherapy

July 6, 2021

Via: ScienceDaily Health

Researchers at Karolinska Institutet in Sweden publish new findings in the journal Cancer Discovery showing how pharmacological activation of the protein p53 boosts the immune response against tumours. The results can be of significance to the development of new combination […]


Biomarker, Innovation

Researchers develop “cell encapsulation” technology to stimulate immunity to fight cancer

May 27, 2021

Via: The Medical News

Immunotherapy techniques developed in oncology to combat cancerous cells have great potential for fighting viruses. A research team from the University Hospitals of Geneva (HUG) and the University of Geneva (UNIGE), in Switzerland, in collaboration with MaxiVAX, a spinoff of […]


Biomarker, Innovation

Crohn’s disease patients have specific IgG antibodies to human bacterial flagellins

May 5, 2021

Via: ScienceDaily Health

Last year, Charles O. Elson, M.D., demonstrated a potential preventive treatment for Crohn’s disease, a form of inflammatory bowel disease. He used a mouse model that included immune-reactive T cells from patients with Crohn’s disease in a flagellin peptide-specific immunotherapy. […]


News

ACGT awards $500,000 to advance immunotherapy approach for treating solid tumors

March 1, 2021

Via: The Medical News

A scientific team led by Brian Brown, PhD, Professor of Genetics and Genomic Sciences and Associate Director of the Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai (New York, New York), has been awarded $500,000 from […]


Innovation, Research

Errant DNA boosts immunotherapy effectiveness

December 17, 2020

Via: ScienceDaily Health

DNA that ends up where it doesn’t belong in cancer cells can unleash an immune response that makes tumors more susceptible to immunotherapy, the results of two UT Southwestern studies indicate. The findings, published online today in Cancer Cell, suggest […]


Biomarker, Innovation

Key blood marker can lead to effective melanoma treatments

October 16, 2020

Via: The Medical News

An Edith Cowan University (ECU) study has revealed that a key blood marker of cancer could be used to select the most effective treatment for melanoma. The discovery, which has the potential to improve melanoma survival rates, was published today […]


Innovation, Research

Study provides insight into lymphomagenesis and patterns of resistance to immunotherapy

September 16, 2020

Via: The Medical News

Lymphomas are a diverse group of cancers of the immune system, which is the body’s primary defense against autoimmune disease, infections, and malignancy. Now, researchers at the University of Tsukuba have clarified risk factors and molecular mechanisms underlying primary and […]


Biomarker, Innovation

Combined immunotherapy approaches increase the effectiveness of cancer treatment

September 11, 2020

Via: The Medical News

Cancer immunotherapy is the manipulation of the immune responses naturally present in the human body to fight cancer. Often, these immune responses are blocked by cells or molecules that prevent them from killing cancer cells, and the tumor is able […]


Biomarker, Innovation, News

Boosting immune memory could reduce cancer recurrence

July 15, 2020

Via: ScienceDaily Health

Immunotherapy drugs that harness the body’s own immune system to fight cancer have revolutionized the treatment of many cancers. They work by blocking checkpoint inhibitor proteins like PD1, removing the brakes from cancer-killing T cells in the immune system. However, […]


Biomarker, Innovation

Engineered killer immune cells target tumors and their immunosuppressive allies

July 7, 2020

Via: ScienceDaily Health

The engineered cell therapy could be used as an alternative approach for treating cancer in patients for whom previous immunotherapy based on the activation of T cells has failed. These findings are reported by researchers at the U.S. National Institutes […]


Biomarker, Innovation

Study identifies a previously unknown mechanism that contributes to intestinal cancer

June 18, 2020

Via: The Medical News

A MedUni Vienna study group has identified a previously unknown mechanism involved in the development of intestinal cancer: The bacterial microbiome activates the so-called immune checkpoint Ido1 in Paneth cells, a special cell that is only found in the gastrointestinal […]


Biomarker, Innovation, Research

FDA OKs First-Line Immunotherapy in Liver Cancer

June 1, 2020

Via: MedPageToday

The FDA on Friday approved the PD-L1 immune checkpoint inhibitor atezolizumab (Tecentriq) for the first-line treatment of unresectable or metastatic liver cancer, in combination with bevacizumab (Avastin), an inhibitor of the VEGF receptor. Approval was based on findings from IMbrave150, […]


Innovation, Patient Experience, Research

Transferring knowledge, not anxiety, can help food-allergic children cope with their fears

February 25, 2020

Via: The Medical News

A new article in Annals of Allergy, Asthma and Immunology, the scientific journal of the American College of Allergy, Asthma and Immunology (ACAAI) discusses the difficulties faced by parents of children with food allergies in not transferring their own anxieties […]


Innovation, Research

Scientists discover novel molecular pathway involved in immunotherapy response

February 20, 2020

Via: The Medical News

Scientists at The Wistar Institute discovered a novel pathway that enables detection of DNA in the cytoplasm and triggers inflammation and cellular senescence. This pathway may be modulated during senescence-inducing chemotherapy to affect cancer cell response to checkpoint inhibitors. Results […]