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Validating the Diagnosis of Depression

April 10, 2018

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In your talk at Pittcon 2018, you mentioned that depression is difficult to diagnose. Please can you outline the current issues with the serotonin hypothesis for diagnosing depression?

It’s very difficult to diagnose depression. To explain this, I like to use the analogy of what you do if you suspect that you have a condition such as diabetes – you visit your doctor who takes blood tests, from which they measure your glucose and insulin levels to deliver a definitive diagnosis. With depression, you can’t open the brain to find answers, and the chemistry of the brain is separate from the chemistry of the body.

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