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Study provides insights into non-oncogenic addictions of tumors

October 9, 2017

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Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) and UC San Diego have shown that tumors can ensure a more reliable nutrient supply by eliminating the p62 protein in surrounding stromal tissue. Specifically, p62 deficiency helps tumors and stroma (supportive tissue outside the tumor) survive and grow, despite being deprived of glutamine, an essential amino acid.

The study, published October 5 in Cell Metabolism, suggests that the p62 pathway in tumor stroma could be a potential anti-cancer target.

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