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The biochemical mechanisms of remdesivir-mediated RNA synthesis inhibition

October 19, 2021

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The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread with rapid devastation throughout the world. The inability to contain its spread without resorting to draconian restrictions on ordinary social interactions and travel showed the urgent need for broad-spectrum antiviral drugs to combat the virus.

A new preprint suggests a fruitful approach to develop such drugs based on biochemical and molecular modeling studies of the drug remdesivir. A preprint version of the study is available on the bioRxiv server while the article undergoes peer review.

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