The ability to edit the genome by altering the DNA sequence inside a living cell is powerful for research and holds enormous promise for the treatment of diseases. However, existing genome editing technologies frequently result in unwanted mutations or can fail to introduce any changes at all. These problems have kept the field from reaching its full potential.
Now, new research from the laboratory of Princeton University researcher Britt Adamson, conducted with collaborators in the lab of Jonathan Weissman, a member of Whitehead Institute and a professor of biology at the Massachussetts Insittute of Technology and an investigator with the Howard Hughes Medical Institute, and Cecilia Cotta-Ramusino, formerly at Editas Medicine, details a novel method called Repair-seq that reveals in exquisite detail how genome editing tools work.
