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New technique offers higher resolution molecular imaging and analysis

May 28, 2020

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The new system, called asymmetrically dispersed spectroscopic single-molecule localization microscopy (SDsSMLM), builds upon existing sSMLM techniques developed at the McCormick School of Engineering to provide more precise spectroscopic single-molecule analysis to study how cells behind certain cancers, or diseases like diabetic retinopathy, function in their localized environments.

While current spectroscopic single-molecule localization microscopy techniques achieve super-resolution imaging and single-molecule spectroscopy simultaneously, current sSMLM designs suffer from reduced imaging resolution and spectral precision. This is caused by the system dividing a finite number of emitted photons — atomic particles that transmit electromagnetic light — between two separate channels for spatial and spectral imaging.

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